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	<title>Chxa.com &#187; Encyclopedia</title>
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	<description>Stem cells, bone marrow: News and research</description>
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		<title>How are stem cells obtained</title>
		<link>http://www.chxa.com/a/how-are-stem-cells-obtained/</link>
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		<pubDate>Fri, 07 Jan 2011 15:30:37 +0000</pubDate>
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		<description><![CDATA[Stem cells hold much promise in bringing about medical breakthroughs in form of treatment for previously incurable diseases and conditions like cancer, Alzheimer&#8217;s disease, Parkinson&#8217;s disease or paralysis. These &#8220;blank&#8221; cells are capable of self-rejuvenation and also transforming into a functional cell; it is these attributes of a stem cell that make them invaluable to [...]]]></description>
			<content:encoded><![CDATA[<p>Stem cells hold much promise in bringing about medical breakthroughs in form of treatment for previously incurable diseases and conditions like cancer, Alzheimer&#8217;s disease, Parkinson&#8217;s disease or paralysis. These &#8220;blank&#8221; cells are capable of self-rejuvenation and also transforming into a functional cell; it is these attributes of a stem cell that make them invaluable to scientists. However, to experiment on the stem cells, they must at first be obtained and the mode of collection is where the controversy originates. There are two main types of stem cells, embryonic and adult stem cells. In order to collect the pluripotent embryonic stem cells, the human embryo must be killed as it can only be extracted from the innermost cellular layers of the blastocyst after just four days of fertilization. It is therefore not hard to understand as why killing a human embryo, which could have otherwise been borne as a human baby, is considered equivalent to murder by a lot of people. Even people who would not go as far as calling it murder, usually admit to the procedure being disturbing in terms of ethics at least. </p>
<p>Adult stem cells come from various sources and contrary to what the name may suggest, it does not only come from fully grown human beings. It is just that they are comparatively grown and different than the embryonic stem cells. The placenta and the umbilical cord blood are both rich sources of adult stem cells, the former being even richer than the latter. Our bone marrow contains multipotent stem cells and it is possible to extract these cells clinically, but the procedure is immensely painful for the donor and may even be considered risky. Unlike the extraction of the embryonic stem cells, extracting adult stem cells is not controversial. Ethicists do not support the killing of an embryo for the sake of medical progress, however bright the future may seem, but bio ethicists do understand the importance of stem cell experimentation and thus do not consider extraction of adult stem cells from various sources to be unethical as long as it is agreed upon voluntarily by the donor or the guardian of the concerned source.</p>
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		<title>Where do stem cells originate</title>
		<link>http://www.chxa.com/a/where-do-stem-cells-originate/</link>
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		<pubDate>Thu, 06 Jan 2011 15:40:42 +0000</pubDate>
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				<category><![CDATA[Encyclopedia]]></category>

		<guid isPermaLink="false">http://www.chxa.com/?p=483</guid>
		<description><![CDATA[If the question is read as an inquiry to the origin and the natural location of stem cells, then the answer would be that it comes from various tissues of the human body. Stem cells in an adult human being are found in the heart, blood, bone marrow, skeletal muscles, skin and fat as well. [...]]]></description>
			<content:encoded><![CDATA[<p>If the question is read as an inquiry to the origin and the natural location of stem cells, then the answer would be that it comes from various tissues of the human body. Stem cells in an adult human being are found in the heart, blood, bone marrow, skeletal muscles, skin and fat as well. After a baby is born, the placenta and the umbilical cord are also found to be rich in stem cells. The placenta however, is much richer in stem cell count than the umbilical cord blood. Embryonic stem cells are among the first cells to develop because it is these that construct all the other tissues and thus the organs, bones, nerves and everything else in our body eventually, by converting into specifically functional cells. </p>
<p>The key factor about stem cells is that they are capable of constant rejuvenation through mitotic cell division and since they are not functional cells, they can transform into any specific type of functional cell, depending on the requirement of the body. Studies related to the possible uses of stem cells in various medical procedures is achieving greater importance with every passing year as scientists keep publishing journals on how the progress is going to improve treatment facilities dramatically. From the ability to repair almost any damaged organ to eliminating previously incurable diseases like cancer or Parkinson&#8217;s disease, it all seems to be in our reach in the near future. In order for the experiments to be successful, scientists must collect necessary amounts of stem cells from various sources. Embryonic stem cells are collected directly from the inside of the blastocyst, roughly a week or so after the egg cell is fertilized, and it is for that reason it is called unethical and have given rise to controversies regarding the extraction of embryonic stem cells. The germline tissues of the abandoned fetus are also a source of stem cell collection. Umbilical cord blood and placenta are the two other sources for collecting adult stem cells. Although not as pluripotent as the stem cells inside an embryo, the adult stem cells are also extracted by scientists from tissues and bone marrow of individuals for different purposes.</p>
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		<title>Magnetic Stem Cells</title>
		<link>http://www.chxa.com/a/magnetic-stem-cells/</link>
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		<pubDate>Wed, 05 Jan 2011 14:37:12 +0000</pubDate>
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				<category><![CDATA[Encyclopedia]]></category>

		<guid isPermaLink="false">http://www.chxa.com/?p=480</guid>
		<description><![CDATA[Magnetic stem cells are one of the latest breakthroughs in the field of medical science as they are believed to hold the potential for next generation cell-level treatment procedures. Stem cells would soon be injected into the patient&#8217;s blood stream to treat and cure heart diseases and vascular problems and the theory is to deliver [...]]]></description>
			<content:encoded><![CDATA[<p>Magnetic <a href="http://www.chxa.com/">stem cells</a> are one of the latest breakthroughs in the field of medical science as they are believed to hold the potential for next generation cell-level treatment procedures. Stem cells would soon be injected into the patient&#8217;s blood stream to treat and cure heart diseases and vascular problems and the theory is to deliver the special stem cells to the area of the injury or disease by guiding them from outside. The magnetism of the cells is what will allow the experts to control the movement of the reparative cells with the help of magnets, once they are injected into the patient&#8217;s body. Scientists have already been successful at directing the magnetized stem cells to the exact area of damage in animals, but the technology is yet to be tried on human beings. </p>
<p>The first part of the procedure involves applying sufficient magnetic nanoparticles on the stem cells to magnetize them, and thus make them controllable. Secondly, these special stem cells are now inserted into the blood stream of the subject with the help of an injection. The final and the most important part of the medical procedure begins next as experts now try to control the direction of the injected magnetic stem cells with the help of a magnet in order to lead them towards the accurate area of the heart damage or anywhere else inside the vascular system for recovery. MRI scans in the USA make use of the same nanomagnets to attain better results already. It is to be noted that the use of magnetic stem cells has a very broad spectrum as far as medical prowess is concerned. From cell therapy to targeting cancerous growths, the scope of using the nanomagnets on stem cells is plenty for repairing the diseased and the injured tissues from inside the body.</p>
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		<title>What is blood composed of</title>
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		<pubDate>Fri, 24 Dec 2010 17:03:22 +0000</pubDate>
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		<guid isPermaLink="false">http://www.chxa.com/?p=472</guid>
		<description><![CDATA[Blood can be divided into two parts basically, the plasma and the blood cells, each of which constitutes about half of the total blood volume. The two parts are defined as follows: 1. Plasma &#8211; Plasma constitutes about 55% of the total blood volume and comprises of 92% water roughly. The rest includes dissolved proteins, [...]]]></description>
			<content:encoded><![CDATA[<p>Blood can be divided into two parts basically, the plasma and the blood cells, each of which constitutes about half of the total blood volume. The two parts are defined as follows: </p>
<p>1. Plasma &#8211; Plasma constitutes about 55% of the total blood volume and comprises of 92% water roughly. The rest includes dissolved proteins, salts, sugar, lipids, vitamins, fat, minerals, enzymes, antibodies, hormones and coagulants. Plasma provides mobility to the blood cells that remain suspended in it and it is due to the mobility which the plasma provides blood with, that the cells are able to receive oxygen and other nutrients from blood constantly, while excreting carbon dioxide and other wastes into it at the same time. Without the blood cells, plasma itself is a mostly clear, yellowish liquid. </p>
<p>2. Blood Cells &#8211; Blood cells can be divided into three major types, white blood cells, red blood cells and platelets. </p>
<p>a) White Blood Cells &#8211; White blood cells or leukocytes are rare in number and constitute approximately 1% of the total blood volume. There is more than one type of white blood cell and all of them together make up our immune system. Unlike the red blood cells which are found in blood only, the leukocytes are also found in the spleen, liver and the lymph glands. </p>
<p>b) Red Blood Cells &#8211; Erythrocytes (RBC) constitute almost half of the blood volume and their main function is to use the hemoglobin in them to carry dissolved oxygen to the cells and also to carry carbon dioxide from the cells for elimination. </p>
<p>c) Platelets &#8211; Like the erythrocytes, platelets do not have nuclei either, and their main function is to stop blood from flowing out of the vessels by releasing coagulating agents near the rupture. Release of proteins that help the immune system to fight with germs is also found to be a function of these cellular fragments recently.</p>
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		<title>What is blood lactate</title>
		<link>http://www.chxa.com/a/what-is-blood-lactate/</link>
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		<pubDate>Fri, 24 Dec 2010 17:01:55 +0000</pubDate>
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		<description><![CDATA[Blood lactate can be defined simply as the lactate that is found dissolved in blood. Exercise that forces anaerobic metabolism instead of aerobic metabolism in an individual&#8217;s muscles and tissues due to inadequate supply of oxygen is usually responsible for the formation of blood lactate. Lactic acid is part of a system that helps the [...]]]></description>
			<content:encoded><![CDATA[<p>Blood lactate can be defined simply as the lactate that is found dissolved in blood. Exercise that forces anaerobic metabolism instead of aerobic metabolism in an individual&#8217;s muscles and tissues due to inadequate supply of oxygen is usually responsible for the formation of blood lactate. Lactic acid is part of a system that helps the body to synthesis Adenosine Triphosphate (ATP) during extremely strenuous and long sessions of physical exercise, which is required for energy production. Through anaerobic glycolysis, it is possible to produce the energy that the body needs immediately, but is not getting through aerobic glycolysis due to lack of oxygen supply. After the glycolysis, pyruvic acid and hydronium ions (H+) are formed, but since there is a deficiency of adequate oxygen, the hydronium ions never combine with oxygen to form water. As a result the Hydronium ions deposited by the NADH remain in the mitochondria of the cell and accumulate as long as the anaerobic glycolysis continues. As the hydronium ion accumulates, the acidity of the cells also increases and in order to counter the effect, pyruvic acid and the hydronium reacts with each other forming lactic acid that dissociate into lactate and hydronium ions again. In order to reduce acidic activity, the lactate carries of a portion of the hydronium ions as it enters blood and it is this lactate that on diffusing into the blood flow with some of the excess hydronium ions is known as blood lactate. As a direct result of hydronium ion accumulation, the pH level in the cells go down from the standard 7.1 to 6.5 or even lower. This is the reason why we cannot move the particular muscle properly after heavy endurance training and also experience pain in the form of a burning sensation on reaching our anaerobic threshold.</p>
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		<title>What is blood ketone</title>
		<link>http://www.chxa.com/a/what-is-blood-ketone/</link>
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		<pubDate>Fri, 24 Dec 2010 17:00:53 +0000</pubDate>
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		<description><![CDATA[Fat is a form of stored energy reserve and our body breaks down fat globules when there is no immediate supply of carbohydrates or energy. When our body taps into our reserved energy source, ketone bodies are formed as a result of the break down and the manufacturing is scientifically termed as ketogenesis. Lack of [...]]]></description>
			<content:encoded><![CDATA[<p>Fat is a form of stored energy reserve and our body breaks down fat globules when there is no immediate supply of carbohydrates or energy. When our body taps into our reserved energy source, ketone bodies are formed as a result of the break down and the manufacturing is scientifically termed as ketogenesis. Lack of carbohydrates in our daily dietary schedule can result in the usage of fat and thus the formation of ketones. Ketones are also formed in blood when our system is unable to utilize the sugar in our blood and thus it must resort to breaking down fat stores. Kidney and liver are the two organs where this process of fat breaking occurs and therefore ketones are also primarily found in these two organs, while they are used mostly by the heart and the brain. Acetone and acetoacetic acid are the two main forms of ketone but beta-hydroxybutyric acid is also considered to be a ketone up to an extent. The main function of the ketone bodies is to supply the brain and the heart with energy after the fat is broken down. </p>
<p>A test which determines the amount of ketones present in the blood of the person is called the serum ketones test. The test is mainly done to check whether the ketogenesis within the person&#8217;s body is above the normal level, which may indicate ketosis. Ketosis is not harmful at the beginning, but there remains a chance that the frequency of ketogenesis in blood may increase further to a point when the patient&#8217;s blood might turn acidic due to a very low pH level. Such an advanced stage is termed as ketoacidosis. The chances of ketoacidosis are high among diabetic patients and thus they check their blood often for increased ketone formation.</p>
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		<title>What is blood serum</title>
		<link>http://www.chxa.com/a/what-is-blood-serum/</link>
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		<pubDate>Fri, 24 Dec 2010 13:27:38 +0000</pubDate>
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		<description><![CDATA[The blood serum is obtained from blood plasma, which is a yellow fluid that acts as a medium of transport for the white and red blood cells along with the nutrients, hormones and antibodies. Blood serum is obtained from this plasma by allowing the collected blood to coagulate and then taking out the yellow fluid. [...]]]></description>
			<content:encoded><![CDATA[<p>The blood serum is obtained from blood plasma, which is a yellow fluid that acts as a medium of transport for the white and red blood cells along with the nutrients, hormones and antibodies. Blood serum is obtained from this plasma by allowing the collected blood to coagulate and then taking out the yellow fluid. Serum is that portion of blood plasma that consists of non-coagulating proteins, antibodies, electrolytes, hormones, microbes and also drugs on occasions but does not contain any cells, white or red and also is made completely free of fibrinogens. Blood serum is mainly used for diagnostic purposes, but it is also required for blood typing. </p>
<p>Blood serum is used for many diagnostic tests like the HCG test to determine pregnancy. Through testing one&#8217;s blood serum, one can come to know of the levels of protein in his/her blood, which is often done to check if the patient is suffering from malnutrition. Low protein levels in one&#8217;s blood may also help to determine the cause of kidney problems. On the contrary, boosted levels of alpha- 1 type proteins can be responsible for rheumatoid arthritis. Some of the common tests that require the blood serum rather than the blood cells include tests for sugar and cholesterol levels. As the serum still contains the hormones that the plasma was carrying, it is also used to check thyroid, insulin and other hormonal levels, depending on the nature and the objective of the medical test. </p>
<p>A non-diagnostic use of serum is as a component in the person&#8217;s own eye drops. They work better than regular eye drops and do not cause allergies for the patient. Apart from the current uses of the blood serum as a diagnostic medium, other more advanced diagnostic tests are also on the verge of development, namely, the early detection of diseases like Parkinson&#8217;s or Alzheimer&#8217;s, which are incurable as of now.</p>
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		<title>What is blood hydrostatic pressure</title>
		<link>http://www.chxa.com/a/what-is-blood-hydrostatic-pressure/</link>
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		<pubDate>Thu, 23 Dec 2010 20:01:15 +0000</pubDate>
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		<description><![CDATA[Hydrostatic pressure refers to any pressure that a liquid exerts on its container. Blood hydrostatic pressure is the pressure that the volume of blood within our circulatory system exerts on the walls of the blood vessels that contain it. However, hydrostatic pressure is not the only pressure that is exerted on a blood vessel, osmotic [...]]]></description>
			<content:encoded><![CDATA[<p>Hydrostatic pressure refers to any pressure that a liquid exerts on its container. Blood hydrostatic pressure is the pressure that the volume of blood within our circulatory system exerts on the walls of the blood vessels that contain it. However, hydrostatic pressure is not the only pressure that is exerted on a blood vessel, osmotic pressure is also present and the cumulative pressure from inside is countered by the same two types of pressure exerted on the outside of the blood vessels by the tissues that surround them. The hydrostatic pressure exerted by our blood on our blood vessels is what we commonly refer to as our blood pressure and it can cause serious problems when upset. </p>
<p>Blood pressure is not the same throughout, for example, the veins and capillaries in our feet have way more pressure inside them than the ones in our head, and gravity is responsible for this particular variation. When we get hypertensive, our blood vessels experience increased hydrostatic pressure on them due to increase of blood flow; it is at this point that arteriosclerosis occurs and as a result, the blood vessels become very hard in order to withstand the high blood pressure. </p>
<p>Blood is essential for us to survive because blood carries all the necessary nutrients along with other materials, both in and out of our cells in a constant circulatory motion. This motion in blood would not be possible without a difference in blood pressure inside the blood vessels and this difference is achieved because there is just one pump that pumps blood, the heart. As the heart pumps blood and the blood passes through the left ventricle all the way to different parts of the body before returning back into the heart through the right atrium, the pressure keeps dropping and is at its lowest point when it re-enters the heart and at its highest immediately after it is pumped out by the heart.</p>
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		<title>What is blood plasma</title>
		<link>http://www.chxa.com/a/what-is-blood-plasma/</link>
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		<pubDate>Thu, 23 Dec 2010 13:26:39 +0000</pubDate>
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		<guid isPermaLink="false">http://www.chxa.com/?p=449</guid>
		<description><![CDATA[Blood plasma acts as the means of transportation for the blood inside an organism. Plasma is the yellowish, intravascular fluid in blood that constitutes roughly 55% of the entire blood volume in our body. Apart from the 90% water, plasma contains hormones, glucose, protein, coagulating agents and electrolytes among others. Blood plasma also carries dissolved [...]]]></description>
			<content:encoded><![CDATA[<p>Blood plasma acts as the means of transportation for the blood inside an organism. Plasma is the yellowish, intravascular fluid in blood that constitutes roughly 55% of the entire blood volume in our body. Apart from the 90% water, plasma contains hormones, glucose, protein, coagulating agents and electrolytes among others. Blood plasma also carries dissolved carbon dioxide as a bodily waste. To separate blood plasma from the blood cells, the collected blood is put into a vial with anti-clotting agents and spun in a centrifuge. Once the white and red blood cells fall at the bottom of the vial due to their weight, the blood plasma is ready to be collected. Although it is generally stated that blood plasma is yellow in color, a person suffering from health problems can also have plasma with a gray tinge to it. </p>
<p>The main function of the blood plasma when it is inside the body is to provide the blood and its other components with mobility. It is this mobility of the blood plasma that serves the entire body in vital ways. The plasma circulates to all parts of the body, while the cells constantly acquire nutrients from and excrete the waste materials into it. As the blood plasma travels throughout the entire body, it continuously replenishes its contents to keep the organism functioning as a whole by serving the needs of all the cells inside the body. Pathogens and germs that are harmful to the body are attacked by the blood cells carried by blood plasma as it circulates. Perhaps the most visible effect of plasma that we see in practice is clotting of blood when we cut ourselves by coagulating agents that it carries. The blood serum, which is essential for most blood diagnostic tests, is obtained by removing coagulants, blood cells and fibrinogens from the plasma.</p>
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		<title>What is blood gulch</title>
		<link>http://www.chxa.com/a/what-is-blood-gulch/</link>
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		<pubDate>Thu, 23 Dec 2010 10:01:02 +0000</pubDate>
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		<description><![CDATA[The reason why Blood Gulch has become so famous is because the machinima series &#8220;Red vs. Blue&#8221; was done on this very scenario. &#8220;Blood Gulch&#8221; is actually a scenario in the popular video game &#8220;Halo: Combat Evolved&#8221;. In the multiplayer mode of Halo, if you select &#8220;Blood Gulch&#8221; as your area of gameplay you will [...]]]></description>
			<content:encoded><![CDATA[<p>The reason why Blood Gulch has become so famous is because the machinima series &#8220;Red vs. Blue&#8221; was done on this very scenario. &#8220;Blood Gulch&#8221; is actually a scenario in the popular video game &#8220;Halo: Combat Evolved&#8221;.  In the multiplayer mode of Halo, if you select &#8220;Blood Gulch&#8221; as your area of gameplay you will find that the level design is rather simplistic and quite straightforward in its approach. The area is a canyon that is surrounded by high hills all around to prevent any way to get out. There are two operational bases within this canyon and in between the two bases; there is a large field that stretches out for the players to battle on, both with and without vehicles. Even as just a level, it had achieved significant popularity in gaming communities around the world. </p>
<p>Due to the Popularity of the Blood Gulch level, it made its reappearance as &#8220;Coagulation&#8221; in the second Halo game. Also in Halo 3, one cannot help but notice a huge similarity between Blood Gulch and &#8220;Valhalla&#8221;. &#8220;Halo Wars&#8221; also had Blood Gulch as a level in the multiplayer mode, but it was only in &#8220;Halo: Reach&#8221; that the developers added much more to the famous multiplayer arena by providing more area for gameplay even outside the Blood Gulch canyon. </p>
<p>Red vs. Blue, which gave the Blood Gulch scenario the popularity it has today, was created by Rooster Teeth Productions as a parody on first-person shooters mainly. As the online videos and DVDs gained a lot of popularity, the project was expanded and it continues till date in form of a mini-series. However, &#8220;Red vs. Blue: The Blood Gulch chronicles&#8221;, which is the original series that started in 2003, finished after its one hundredth episode on June 28th, 2007.</p>
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