Discussion Our meta-analysis found that the diagnostic sensitivity for saliva NAAT is approximately 83.2% (95% CrI, 74.7%-91.4%), which is comparable to that reported for nasopharyngeal swab NAAT and to the result obtained using our latent class model analysis (84.8%; 95% CrI, 76.8%-92.4%). Given the ease of sample procurement and increased patient comfort, testing centers should strongly…Read More
Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice.
Gene-engineered CD34(+) hematopoietic stem and progenitor cells (HSPCs) can be utilized to generate an HIV-1-resistant immune system. Nevertheless, a sure threshold of transduced HSPCs is perhaps required for transplantation into mice for creating an HIV-resistant immune system. On this examine, we mixed CCR5 knockdown by a extremely environment friendly microRNA (miRNA) lentivector with pretransplantation number…Read More