Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant

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The D614G mutation within the Spike protein of the SARS-CoV-2 has successfully changed the early pandemic-causing variant. Utilizing pseudotyped lentivectors, we confirmed that the aspartate substitute by glycine in place 614 is markedly extra infectious. Molecular modelling means that the G614 mutation facilitates transition in the direction of an open state of the Spike protein. To…