Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells

Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells

Angelman Syndrome is a uncommon neurodevelopmental dysfunction characterised by impaired communication expertise, ataxia, motor and steadiness deficits, mental disabilities, and seizures. The genetic reason for Angelman syndrome is the neuronal lack of UBE3A expression within the mind.
A novel method, described right here, is a stem cell gene remedy which makes use of lentivector transduced hematopoietic stem and progenitor cells to ship useful UBE3A to affected cells. We have now demonstrated each the prevention and reversal of Angelman syndrome phenotypes upon transplantation and engraftment of human CD34+ cells transduced with a Ube3a lentivector in a novel immunodeficient Ube3amat-/pat+ IL2rg-/y mouse mannequin of Angelman syndrome.
A major enchancment in motor and cognitive behavioral assays in addition to normalized delta energy measured by EEG was noticed in neonates and adults transplanted with the gene modified cells. Human hematopoietic profiles noticed within the lymphoid organs by detection of human immune cells had been regular.
Expression of UBE3A was detected within the brains of the grownup therapy group following immunohistochemical staining illustrating engraftment of the gene modified cells expressing UBE3A within the mind. As demonstrated with our information, this stem cell gene remedy method affords a promising therapy technique for Angelman syndrome, not requiring a vital therapy window.

ZVex™, a dendritic-cell-tropic lentivector, primes protecting antitumor T cell responses which can be considerably boosted utilizing heterologous vaccine modalities

Therapeutic most cancers vaccines should induce excessive ranges of tumor-specific cytotoxic CD8 T cells to be efficient. We present right here that tumor-antigen particular effector and reminiscence T cell responses primed with a non-integrating, dendritic-cell focused lentiviral vector (ZVex™) could possibly be boosted considerably by both adjuvanted recombinant protein, adenoviral vectors, or self-replicating RNA.
These heterologous prime-boost regimens additionally supplied considerably higher safety in murine tumor fashions. In distinction, homologous prime-boost regimens, or utilizing the lentiviral vector as a lift, resulted in decrease T cell responses with restricted therapeutic efficacy. Heterologous prime-boost regimens that make the most of ZVex because the prime could also be enticing modalities for therapeutic most cancers vaccines.

Extremely environment friendly ‘hit-and-run’ genome modifying with unconcentrated lentivectors carrying Vpr.Prot.Cas9 protein produced from RRE-containing transcripts

The appliance of gene-editing know-how is presently restricted by the dearth of protected and environment friendly strategies to ship RNA-guided endonucleases to focus on cells. We engineered lentivirus-based nanoparticles to co-package the U6-sgRNA template and the CRISPR-associated protein 9 (Cas9) fused with a virion-targeted protein Vpr (Vpr.Prot.Cas9), for simultaneous supply to cells.
Equal spatiotemporal management of the vpr.prot.cas9 and gag/pol gene expression (the presence of Rev responsive aspect, RRE) drastically enhanced the encapsidation of the fusion protein and resulted within the manufacturing of extremely environment friendly lentivector nanoparticles. Transduction of the unconcentrated, Vpr.Prot.Cas9-containing vectors led to >98% disruption of the EGFP gene in reporter HEK293-EGFP cells with minimal cytotoxicity.
Moreover, we detected indels within the focused endogenous loci at frequencies of as much as 100% in cell traces derived from lymphocytes and monocytes and as much as 15% in major CD4+ T cells by high-throughput sequencing. This method might present a platform for the environment friendly, dose-controlled and tissue-specific supply of genome modifying enzymes to cells and it could be appropriate for simultaneous endogenous gene disruption and a transgene supply.

A single lentivector DNA based mostly immunization accommodates a late heterologous SIVmac251 mucosal problem an infection.

Number of typical vaccine methods examined towards HIV-1 have did not induce safety towards HIV acquisition or sturdy management of viremia. Subsequently, modern methods that may induce lengthy lasting protecting immunity towards HIV continual an infection are wanted. Lately, we developed an integration-defective HIV lentiDNA vaccine that undergoes a single cycle of replication in goal cells wherein most viral antigens are produced.
A single immunization with such lentiDNA induced long-lasting T-cell and modest antibody responses in cynomolgus macaques. Right here eighteen months after this single immunization, all animals had been subjected to repeated low dose intra-rectal challenges with a heterologous pathogenic SIVmac251 isolate.
Though the viral set level in SIVmac-infected cynomolgus is often decrease than that seen in Indian rhesus macaques, the vaccinated group of macaques displayed a two log discount of peak of viremia adopted by a progressive and sustained management of virus replication relative to manage animals.
This antiviral management correlated with antigen-specific CD4+ and CD8+ T cells with excessive capability of recall responses comprising effector and central reminiscence T cells but additionally reminiscence T cell precursors. That is the primary description of SIV management in NHP mannequin contaminated at 18 months following a single immunization with a non-integrative single cycle lentiDNA HIV vaccine.
Whereas not delivering sterilizing immunity, our single immunization technique with a single-cycle lentivector DNA vaccine seems to offer an fascinating and protected vaccine platform that warrants additional exploration.

Use of Heterologous Vesiculovirus G Proteins Circumvents the Humoral Anti-envelope Immunity in Lentivector-Primarily based In Vivo Gene Supply.

Vesicular stomatitis virus Indiana pressure glycoprotein (VSVind.G) mediates broad tissue tropism and environment friendly mobile uptake. Lentiviral vectors (LVs) are notably promising, as they’ll effectively transduce non-dividing cells and facilitate steady genomic transgene integration; due to this fact, LVs have an infinite untapped potential for gene remedy purposes, however the improvement of humoral and cell-mediated anti-vector responses might prohibit their efficacy.
We hypothesized that G proteins from totally different members of the vesiculovirus genus may enable the technology of a panel of serotypically distinct LV pseudotypes with potential for repeated in vivo administration.
Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells
We discovered that mice hyperimmunized with VSVind.G weren’t transduced to any important diploma following intravenous injection of LVs with VSVind.G envelopes, in keeping with the thesis that a number of LV administrations would doubtless be blunted by an adaptive immune response.
Excitingly, bioluminescence imaging research demonstrated that the VSVind-neutralizing response could possibly be evaded by LV pseudotyped with Piry and, to a lesser extent, Cocal virus glycoproteins. Heterologous dosing regimens utilizing viral vectors and oncolytic viruses with Piry and Cocal envelopes might signify a novel technique to attain repeated vector-based interventions, unfettered by pre-existing anti-envelope antibodies.

Characterizing the encapsulation and launch of lentivectors and adeno-associated vectors from degradable alginate hydrogels.

Gene remedy utilizing viral vectors has been licensed for scientific use each within the European Union and the USA. Lentivectors (LV) and adeno-associated vectors (AAV) are two promising and FDA accredited gene-therapy viral vectors. Many future purposes of those vectors will profit from focusing on particular areas of curiosity throughout the physique.
Subsequently, constructing on the early success of those vectors might rely upon discovering efficient supply programs to localize therapeutic administration. Degradable alginate hydrogels have been examined as interesting supply automobiles for the managed supply of vector payloads. On this research, we examine the flexibility of two totally different degradable alginate hydrogel formulations to effectively ship LV and AAV.
We suggest that launch charges of viral vectors are depending on the bodily properties of each the hydrogels and vectors. Right here, we reveal that the preliminary power and degradation charge of alginate hydrogels supplies levers of management for tuning LV launch however don’t present management within the launch of AAV.
Whereas each alginate formulations used confirmed sustained launch of each LV and AAV, LV launch was proven to be depending on alginate hydrogel degradation, whereas AAV launch was largely ruled by diffusive mechanisms.

Mcoln1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL512633 5 µg/vial Ask for price

MCOLN2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV632485 1.0 ug DNA
EUR 818.4

MCOLN2 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV632489 1.0 ug DNA
EUR 818.4

MCOLN2 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV632490 1.0 ug DNA
EUR 818.4

MCOLN2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV632486 1.0 ug DNA
EUR 818.4

MCOLN2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV632487 1.0 ug DNA
EUR 888

MCOLN2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV632488 1.0 ug DNA
EUR 888

Mcoln3 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL701568 5 µg/vial Ask for price

Mcoln2 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL703592 5 µg/vial Ask for price

MCOLN3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL303305 5 µg/vial Ask for price

MCOLN2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL303306 5 µg/vial Ask for price

Mcoln2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL504128 5 µg/vial Ask for price

Mcoln3 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL506106 5 µg/vial Ask for price

Mcoln1 ORF Vector (Rat) (pORF)

ORF070382 1.0 ug DNA
EUR 607.2

Mcoln1 ORF Vector (Mouse) (pORF)

ORF049952 1.0 ug DNA
EUR 607.2

MCOLN1 ORF Vector (Human) (pORF)

ORF006340 1.0 ug DNA
EUR 114

MCOLN1 Protein Vector (Rat) (pPM-C-HA)

PV281528 500 ng
EUR 723.6

MCOLN1 Protein Vector (Rat) (pPB-C-His)

PV281526 500 ng
EUR 723.6

MCOLN1 Protein Vector (Rat) (pPB-N-His)

PV281527 500 ng
EUR 723.6

MCOLN1 Protein Vector (Rat) (pPM-C-His)

PV281529 500 ng
EUR 723.6

MCOLN1 Protein Vector (Human) (pPM-C-HA)

PV025359 500 ng
EUR 394.8

MCOLN1 Protein Vector (Mouse) (pPM-C-HA)

PV199808 500 ng
EUR 723.6

MCOLN1 Protein Vector (Human) (pPB-C-His)

PV025357 500 ng
EUR 394.8

MCOLN1 Protein Vector (Human) (pPB-N-His)

PV025358 500 ng
EUR 394.8

MCOLN1 Protein Vector (Human) (pPM-C-His)

PV025360 500 ng
EUR 394.8

MCOLN1 Protein Vector (Mouse) (pPB-C-His)

PV199806 500 ng
EUR 723.6

MCOLN1 Protein Vector (Mouse) (pPB-N-His)

PV199807 500 ng
EUR 723.6

MCOLN1 Protein Vector (Mouse) (pPM-C-His)

PV199809 500 ng
EUR 723.6

Mcoln1 - Rat shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL704498V 500 ul each Ask for price

MCOLN1 - Human shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL303307V 500 ul each Ask for price

Mcoln1 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL512633V 500 ul each Ask for price

Lenti ORF clone of Mcoln1 (mGFP-tagged) - Mouse mucolipin 1 (Mcoln1)

MR225390L4 10 µg Ask for price

Lenti ORF clone of Mcoln1 (Myc-DDK-tagged) - Mouse mucolipin 1 (Mcoln1)

MR225390L3 10 µg Ask for price

MCOLN1

CSB-CL872417HU 10 μg plasmid + 200μl Glycerol Ask for price

Mcoln1 sgRNA CRISPR Lentivector set (Rat)

K6717101 3 x 1.0 ug
EUR 406.8

MCOLN1 (untagged)-Human mucolipin 1 (MCOLN1)

SC319381 10 µg Ask for price

Lenti ORF clone of Mcoln1 (mGFP-tagged ORF) - Rat mucolipin 1 (Mcoln1), (10 ug)

RR212292L4 10 µg Ask for price

MCOLN1 sgRNA CRISPR Lentivector set (Human)

K1281301 3 x 1.0 ug
EUR 406.8

Mcoln1 sgRNA CRISPR Lentivector set (Mouse)

K4111301 3 x 1.0 ug
EUR 406.8

Lenti ORF particles, Mcoln1 (GFP-tagged) - Mouse mucolipin 1 (Mcoln1), 200ul, >10^7 TU/mL

MR225390L4V 200 µl Ask for price

Lenti ORF particles, MCOLN1 (mGFP-tagged) - Human mucolipin 1 (MCOLN1), 200ul, >10^7 TU/mL

RC201010L2V 200 µl Ask for price

Lenti ORF particles, MCOLN1 (mGFP-tagged) - Human mucolipin 1 (MCOLN1), 200ul, >10^7 TU/mL

RC201010L4V 200 µl Ask for price

Lenti ORF clone of Mcoln1 (Myc-DDK-tagged ORF) - Rat mucolipin 1 (Mcoln1), (10 ug)

RR212292L3 10 µg Ask for price

MCOLN1 (GFP-tagged) - Human mucolipin 1 (MCOLN1)

RG201010 10 µg Ask for price

Lenti ORF particles, Mcoln1 (GFP-tagged ORF) - Rat mucolipin 1 (Mcoln1), 200ul, >10^7 TU/mL

RR212292L4V 200 µl Ask for price

Mcoln1 (untagged) - Mouse mucolipin 1 (Mcoln1), (10ug)

MC219324 10 µg Ask for price

Lenti ORF particles, MCOLN1 (Myc-DDK tagged) - Human mucolipin 1 (MCOLN1), 200ul, >10^7 TU/mL

RC201010L1V 200 µl Ask for price

Lenti ORF particles, MCOLN1 (Myc-DDK tagged) - Human mucolipin 1 (MCOLN1), 200ul, >10^7 TU/mL

RC201010L3V 200 µl Ask for price

Mcoln1 - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR704498 5 µg/vial Ask for price

Lenti ORF particles, Mcoln1 (Myc-DDK-tagged) - Mouse mucolipin 1 (Mcoln1), 200ul, >10^7 TU/mL

MR225390L3V 200 µl Ask for price

Mcoln1 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6717102 1.0 ug DNA
EUR 184.8

Mcoln1 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6717103 1.0 ug DNA
EUR 184.8

Mcoln1 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6717104 1.0 ug DNA
EUR 184.8

Mcoln1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR512633 5 µg/vial Ask for price

MCOLN1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR303307 5 µg/vial Ask for price

MCOLN1 sgRNA CRISPR Lentivector (Human) (Target 1)

K1281302 1.0 ug DNA
EUR 184.8

MCOLN1 sgRNA CRISPR Lentivector (Human) (Target 2)

K1281303 1.0 ug DNA
EUR 184.8

MCOLN1 sgRNA CRISPR Lentivector (Human) (Target 3)

K1281304 1.0 ug DNA
EUR 184.8

Mcoln1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4111302 1.0 ug DNA
EUR 184.8

Mcoln1 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4111303 1.0 ug DNA
EUR 184.8

Mcoln1 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4111304 1.0 ug DNA
EUR 184.8

MCOLN1 siRNA

20-abx923751
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  • 15 nmol
  • 30 nmol

MCOLN1 siRNA

20-abx923752
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  • 15 nmol
  • 30 nmol

Lenti ORF particles, Mcoln1 (Myc-DDK-tagged ORF) - Rat mucolipin 1 (Mcoln1), 200ul, >10^7 TU/mL

RR212292L3V 200 µl Ask for price

MCOLN1 Peptide

MBS3227499-01mg 0.1mg
EUR 180

MCOLN1 Peptide

MBS3227499-5x01mg 5x0.1mg
EUR 730

Mcoln1 (GFP-tagged) - Mouse mucolipin 1 (Mcoln1), (10ug)

MG225390 10 µg Ask for price

Mcoln1 (Myc-DDK-tagged) - Mouse mucolipin 1 (Mcoln1)

MR225390 10 µg Ask for price

MCOLN1 (Myc-DDK-tagged)-Human mucolipin 1 (MCOLN1)

RC201010 10 µg Ask for price

MCOLN1 Antibody

GWB-D34618 0.05 mg Ask for price

Mcoln1 (untagged ORF) - Rat mucolipin 1 (Mcoln1), (10 ug)

RN212292 10 µg Ask for price

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin)

MBS6007836-02mL 0.2(mL
EUR 695

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin)

MBS6007836-5x02mL 5x0.2mL
EUR 2975

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (AP)

MBS6319738-02mL 0.2mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (AP)

MBS6319738-5x02mL 5x0.2mL
EUR 4250

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (PE)

MBS6319748-02mL 0.2mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (PE)

MBS6319748-5x02mL 5x0.2mL
EUR 4250

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (APC)

MBS6319739-02mL 0.2mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (APC)

MBS6319739-5x02mL 5x0.2mL
EUR 4250

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (FITC)

MBS6319741-02mL 0.2mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (FITC)

MBS6319741-5x02mL 5x0.2mL
EUR 4250

MCOLN1 cDNA Clone

MBS1270766-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 330

MCOLN1 cDNA Clone

MBS1270766-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 1430

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (Biotin)

MBS6319740-02mL 0.2mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (Biotin)

MBS6319740-5x02mL 5x0.2mL
EUR 4250

MCOLN1 siRNA (Mouse)

MBS8202237-15nmol 15nmol
EUR 405

MCOLN1 siRNA (Mouse)

MBS8202237-30nmol 30nmol
EUR 565

MCOLN1 siRNA (Mouse)

MBS8202237-5x30nmol 5x30nmol
EUR 2450

MCOLN1 siRNA (Human)

MBS8229712-15nmol 15nmol
EUR 405

MCOLN1 siRNA (Human)

MBS8229712-30nmol 30nmol
EUR 565

MCOLN1 siRNA (Human)

MBS8229712-5x30nmol 5x30nmol
EUR 2450

Mcoln1 (Myc-DDK-tagged ORF) - Rat mucolipin 1 (Mcoln1), (10 ug)

RR212292 10 µg Ask for price

MCOLN1 cloning plasmid

CSB-CL872417HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the MCOLN1 gene.

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6717105 3 x 1.0 ug
EUR 451.2

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 405)

MBS6319743-01mL 0.1mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 405)

MBS6319743-5x01mL 5x0.1mL
EUR 4250

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 490)

MBS6319744-01mL 0.1mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 490)

MBS6319744-5x01mL 5x0.1mL
EUR 4250

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 550)

MBS6319745-01mL 0.1mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 550)

MBS6319745-5x01mL 5x0.1mL
EUR 4250

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 650)

MBS6319746-01mL 0.1mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 650)

MBS6319746-5x01mL 5x0.1mL
EUR 4250

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 750)

MBS6319747-01mL 0.1mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (MaxLight 750)

MBS6319747-5x01mL 5x0.1mL
EUR 4250

MCOLN1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1281305 3 x 1.0 ug
EUR 451.2

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K4111305 3 x 1.0 ug
EUR 451.2

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (Azide free) (HRP)

MBS6319742-02mL 0.2mL
EUR 980

MCOLN1, CT (MCOLN1, ML4, Mucolipin-1, MG-2, Mucolipidin) (Azide free) (HRP)

MBS6319742-5x02mL 5x0.2mL
EUR 4250

Mouse Mcoln1 ELISA Kit

EF015572 96tests
EUR 566

Human MCOLN1 ELISA KIT

EF005299 96tests
EUR 566

MCOLN1 Antibody (C-term)

MBS9205163-008mL 0.08mL
EUR 210

MCOLN1 Antibody (C-term)

MBS9205163-04mL 0.4mL
EUR 430

MCOLN1 Antibody (C-term)

MBS9205163-5x04mL 5x0.4mL
EUR 1910

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K6717106 1.0 ug DNA
EUR 200.4

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K6717107 1.0 ug DNA
EUR 200.4

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K6717108 1.0 ug DNA
EUR 200.4

Mouse MCOLN1 shRNA Plasmid

20-abx979279
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  • 150 µg
  • 300 µg

Human MCOLN1 shRNA Plasmid

20-abx961390
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  • Ask for price
  • 150 µg
  • 300 µg

MCOLN1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1281306 1.0 ug DNA
EUR 200.4

MCOLN1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1281307 1.0 ug DNA
EUR 200.4

MCOLN1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1281308 1.0 ug DNA
EUR 200.4

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K4111306 1.0 ug DNA
EUR 200.4

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K4111307 1.0 ug DNA
EUR 200.4

Mcoln1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K4111308 1.0 ug DNA
EUR 200.4

Mcoln3 - Rat shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL701568V 500 ul each Ask for price

Mcoln2 - Rat shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL703592V 500 ul each Ask for price

Human MCOLN1 Protein Lysate

MBS8415063-002mg 0.02mg
EUR 365

Human MCOLN1 Protein Lysate

MBS8415063-5x002mg 5x0.02mg
EUR 1410

Mucolipin 1 (MCOLN1) Antibody

abx027461-400ul 400 ul
EUR 627.6

Mucolipin 1 (MCOLN1) Antibody

abx027461-80l 80 µl
EUR 343.2

Mucolipin 1 (MCOLN1) Antibody

abx027461-400l 400 µl
EUR 518.75

MCOLN1 Recombinant Protein (Rat)

RP211142 100 ug Ask for price

AAP35307-100UG - MCOLN1 Peptide

AAP35307-100UG 100ug
EUR 99

MCOLN3 - Human shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL303305V 500 ul each Ask for price

MCOLN2 - Human shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL303306V 500 ul each Ask for price

Mcoln2 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL504128V 500 ul each Ask for price

Mcoln3 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL506106V 500 ul each Ask for price

MCOLN1 Recombinant Protein (Human)

RP019018 100 ug Ask for price

MCOLN1 Recombinant Protein (Mouse)

RP149852 100 ug Ask for price

MCOLN1 Rabbit Polyclonal Antibody

E10G35086 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Lenti ORF clone of Human mucolipin 1 (MCOLN1), mGFP tagged

RC201010L2 10 µg Ask for price

Lenti ORF clone of Human mucolipin 1 (MCOLN1), mGFP tagged

RC201010L4 10 µg Ask for price

Human MCOLN1 knockout cell line

ABC-KH9118 1 vial Ask for price
Description: Human MCOLN1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.
Altogether, this research demonstrates alginate’s use as a attainable supply platform for LV and, for the primary time, AAV – highlighting the potential of injectable degradable alginate hydrogels for use as a flexible supply software in gene remedy purposes.

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