An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells.

An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells.

Dendritic cells (DCs) play a predominant function in initiating cell immune responses. Right here we generated a DC-targeting lentiviral vector (LVDC-UbHBcAg-LIGHT) and evaluated its capability to elicit HBV-specific cytotoxic T lymphocyte (CTL) responses. DC-SIGN-mediated particular transduction utilizing this assemble was confirmed in DC-SIGN-expressing 293T cells and ex vivo-cultured bone marrow cells.
LVDC-UbHBcAg-LIGHT-loaded DCs have been extremely efficient in inducing HBV-specific CTLs. Mechanistic research demonstrated autophagy blocking led to a big improve in apoptosis and apparent inhibition of CD8 + T cells entry into S-phase, correspondingly attenuated LVDC-UbHBcAg-LIGHT-loaded DC-induced T cell responses.
This remark was supported by accumulation of pro-apoptotic proteins and the principle detrimental cell cycle regulator-CDKN1B that in any other case can be degraded in activated T cells the place autophagy preferentially occured. Our findings revealed an vital function of autophagy within the activation of T cells and recommended LVDC-UbHBcAg-LIGHT could probably be used as a therapeutic technique to fight persistent HBV an infection with greater safety.

Lentivector Producer Cell Traces with Stably Expressed Vesiculovirus Envelopes.

Retroviral and lentiviral vectors typically use the envelope G protein from the vesicular stomatitis virus Indiana pressure (VSVind.G). Nevertheless, lentivector producer cell traces that stably specific VSVind.G haven’t been reported, presumably due to its cytotoxicity, stopping easy scale-up of vector manufacturing.
Apparently, we confirmed that VSVind.G and different vesiculovirus G from the VSV New Jersey pressure (VSVnj), Cocal virus (COCV), and Piry virus (PIRYV) could possibly be constitutively expressed and supported lentivector manufacturing for as much as 10 weeks.
All G-enveloped particles have been strong, permitting focus and freeze-thawing. COCV.G and PIRYV.G have been resistant to enhance inactivation, and, utilizing chimeras between VSVind.G and COCV.G, the determinant for complement inactivation of VSVind.G was mapped to amino acid residues 136-370. Clonal packaging cell traces utilizing COCV.G could possibly be generated; nonetheless, throughout makes an attempt to determine LV producer cells, vector superinfection was noticed following the introduction of a lentivector genome.
This could possibly be prevented by culturing the cells with the antiviral drug nevirapine. Instead countermeasure, we demonstrated that useful lentivectors could possibly be reconstituted by admixing supernatant from steady cells producing unenveloped virus with supernatant containing envelopes harvested from cells stably expressing VSVind.G, COCV.G, or PIRYV.G.

Microgels produced utilizing microfluidic on-chip polymer mixing for managed launched of VEGF encoding lentivectors.

Alginate hydrogels are broadly used as supply autos as a consequence of their means to encapsulate and launch a variety of cargos in a delicate and biocompatible method. The discharge of encapsulated therapeutic cargos might be promoted or stunted by adjusting the hydrogel physiochemical properties. Nevertheless, the discharge from such techniques is commonly skewed in direction of burst-release or prolonged retention.
To handle this, we hypothesized that the general magnitude of burst launch could possibly be adjusted by combining microgels with distinct properties and launch conduct. Microgel suspensions have been generated utilizing a course of we have now termed on-chip polymer mixing to yield composite suspensions of a variety of microgel formulations.
On this method, we studied how alginate share and degradation relate to the discharge of lentivectors. Whereas modifications in alginate share had a minimal impression on lentivector launch, microgel degradation led to a 3-fold improve, and close to full launch, over 10 days.
Moreover, by controlling the quantity of degradable alginate current inside microgels the relative fee of launch might be adjusted. A degradable formulation of microgels was used to ship vascular endothelial development issue (VEGF)-encoding lentivectors within the chick chorioallantoic membrane (CAM) assay and yielded a proangiogenic response compared to the identical lentivectors delivered in suspension. The utility of blended microgel suspensions could present an particularly interesting platform for the supply of lentivectors or equally sized therapeutics.

Diminished Reminiscence T-Cell Enlargement Resulting from Delayed Kinetics of Antigen Expression by Lentivectors.

Reminiscence CD8(+) T lymphocytes play a central function in protecting immunity. In try to extend the frequencies of reminiscence CD8(+) T cells, repeated immunizations with viral vectors are usually explored. Lentivectors have emerged as a robust vaccine modality with comparatively low pre-existing and anti-vector immunity, thus, regarded as superb for reinforcing reminiscence T cells.
Nonetheless, we discovered that lentivectors elicited diminished secondary T-cell responses that didn’t exceed these obtained by priming. This was not because of the presence of anti-vector immunity, as restricted secondary responses have been additionally noticed following heterologous prime-boost immunizations.
By dissecting the mechanisms concerned on this course of, we exhibit that lentivectors set off exceptionally gradual kinetics of antigen expression, whereas optimum activation of lentivector-induced T cells relays on sturdy expression of the antigen.
These qualities hamper secondary responses, since lentivector-encoded antigen is quickly cleared by major cytotoxic T cells that restrict its presentation by dendritic cells. Certainly, blocking antigen clearance by cytotoxic T cells by way of FTY720 remedy, totally restored antigen presentation.
Taken collectively, whereas low antigen expression is anticipated throughout secondary immunization with any vaccine vector, our outcomes reveal that the intrinsic delayed expression kinetics of lentiviral-encoded antigen, additional dampens secondary CD8(+) T-cell growth.
Breast most cancers immunotherapy is a potent remedy choice, with antibody therapies akin to trastuzumab rising 2-year survival charges by 50%. Nevertheless, lively immunotherapy via vaccination has usually been clinically ineffective.
One potential technique of enhancing vaccine remedy is by delivering breast most cancers antigens to dendritic cells (DCs) for enhanced antigen presentation. To perform this in vivo, we pseudotyped lentiviral vector (LV) vaccines with a modified Sindbis Virus glycoprotein in order that they might ship genes encoding the breast most cancers antigen alpha-lactalbumin (Lalba) or erb-b2 receptor tyrosine kinase 2 (ERBB2 or HER2) on to resident DCs.
 An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells.
We hypothesized that using these DC-targeting lentiviral vectors asa breast most cancers vaccine might result in an improved immune response towards self-antigens present in breast most cancers tumors. Certainly, single injections of the vaccine vectors have been capable of amplify antigen-specific CD8T cells 4-6-fold over naïve mice, just like the perfect revealed vaccine regimens.
Immunization of those mice fully inhibited tumor development in a overseas antigen atmosphere (LV-ERBB2 in wildtype mice), and it decreased the speed of tumor development in a self-antigen atmosphere (LV-Lalba in wildtype or LV-ERBB2 in MMTV-huHER2 transgenic).

KRTAP5-4 Protein Vector (Human) (pPB-C-His)

PV090222 500 ng Ask for price

KRTAP5-4 Protein Vector (Human) (pPB-N-His)

PV090223 500 ng Ask for price

KRTAP5-4 Protein Vector (Human) (pPM-C-HA)

PV090224 500 ng Ask for price

KRTAP5-4 Protein Vector (Human) (pPM-C-His)

PV090225 500 ng Ask for price

KRTAP5-4 Protein Vector (Mouse) (pPB-C-His)

PV195566 500 ng
EUR 723.6

KRTAP5-4 Protein Vector (Mouse) (pPB-N-His)

PV195567 500 ng
EUR 723.6

KRTAP5-4 Protein Vector (Mouse) (pPM-C-HA)

PV195568 500 ng
EUR 723.6

KRTAP5-4 Protein Vector (Mouse) (pPM-C-His)

PV195569 500 ng
EUR 723.6

KRTAP5-4 sgRNA CRISPR Lentivector set (Human)

K1182801 3 x 1.0 ug
EUR 406.8

Krtap5-4 sgRNA CRISPR Lentivector set (Mouse)

K3047101 3 x 1.0 ug
EUR 406.8

IL-4 Interleukin 4 Human Recombinant Protein, Yeast

PROTP05112-4 Regular: 10ug
EUR 380.4
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques.

Mouse Keratin- associated protein 5- 4, Krtap5-4 ELISA KIT

ELI-23319m 96 Tests
EUR 1038

Human Keratin- associated protein 5- 4, KRTAP5-4 ELISA KIT

ELI-12493h 96 Tests
EUR 988.8

Individual Reaction Mix 4

G065-4 200 reactions
EUR 200.4

KRTAP5-4 sgRNA CRISPR Lentivector (Human) (Target 1)

K1182802 1.0 ug DNA
EUR 184.8

KRTAP5-4 sgRNA CRISPR Lentivector (Human) (Target 2)

K1182803 1.0 ug DNA
EUR 184.8

KRTAP5-4 sgRNA CRISPR Lentivector (Human) (Target 3)

K1182804 1.0 ug DNA
EUR 184.8

Krtap5-4 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3047102 1.0 ug DNA
EUR 184.8

Krtap5-4 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3047103 1.0 ug DNA
EUR 184.8

Krtap5-4 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3047104 1.0 ug DNA
EUR 184.8

KRTAP5-4 3'UTR GFP Stable Cell Line

TU062129 1.0 ml
EUR 1672.8

Krtap5-4 3'UTR Luciferase Stable Cell Line

TU110840 1.0 ml Ask for price

Krtap5-4 3'UTR GFP Stable Cell Line

TU160840 1.0 ml Ask for price

KRTAP5-4 3'UTR Luciferase Stable Cell Line

TU012129 1.0 ml
EUR 1672.8

KRTAP5-13P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV730661 1.0 ug DNA Ask for price

KRTAP5-13P Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV730665 1.0 ug DNA Ask for price

KRTAP5-13P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV730666 1.0 ug DNA Ask for price

KRTAP5-14P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV730667 1.0 ug DNA Ask for price

KRTAP5-14P Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV730671 1.0 ug DNA Ask for price

KRTAP5-14P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV730672 1.0 ug DNA Ask for price

pLenti-CLDN1 shRNA-4 Plasmid

PVTBAV04867-4 2 ug
EUR 427.2

Feline IL-4 Recombinant Protein

R00230-4 5ug/vial
EUR 310.8
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Digital Shaker For 4 Microplates

6782-4 EACH
EUR 1110.36

DIGITAL SHAKER FOR 4 MICROPLATES, 120V

6780-4 1/pk
EUR 957.6
Description: Lab Equipment; Shakers & Mixers

Mouse FibrOut 4, for brain, neural

4-20507 1 ml Ask for price

Mouse FibrOut 4, for brain, neural

4-20508 5 x 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20533 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20534 5 x 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21553 5 x 1 ml Ask for price

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 380.4
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 380.4
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

ICP-MS Multi-Element Solution 4

CLMS-4 125ML
EUR 221.16

KRTAP5-10 siRNA

20-abx922130
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-11 siRNA

20-abx922131
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-1 siRNA

20-abx922132
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-1 siRNA

20-abx922133
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-2 siRNA

20-abx922134
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-2 siRNA

20-abx922135
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-3 siRNA

20-abx922136
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-5 siRNA

20-abx922139
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-5 siRNA

20-abx922140
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-6 siRNA

20-abx922141
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-7 siRNA

20-abx922142
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-8 siRNA

20-abx922143
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

KRTAP5-9 siRNA

20-abx922144
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Bone Dissociation System 4 (Osteoblasts), Adult Mouse

4-20214 ea Ask for price

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Pituitary Dissociation System 4 (Pituitary), Adult mouse

4-20404 ea Ask for price

Thymus Dissociation System 4 (Epithelial), Adult rat

4-20444 ea Ask for price

KRTAP5-9 ORF Vector (Human) (pORF)

ORF005808 1.0 ug DNA
EUR 114

KRTAP5-6 ORF Vector (Human) (pORF)

ORF013536 1.0 ug DNA
EUR 424.8

Krtap5-1 ORF Vector (Mouse) (pORF)

ORF048889 1.0 ug DNA
EUR 607.2

Krtap5-2 ORF Vector (Mouse) (pORF)

ORF048890 1.0 ug DNA
EUR 607.2

Krtap5-3 ORF Vector (Mouse) (pORF)

ORF048891 1.0 ug DNA
EUR 607.2

Krtap5-5 ORF Vector (Mouse) (pORF)

ORF048893 1.0 ug DNA
EUR 607.2

KRTAP5-1 ORF Vector (Human) (pORF)

ORF022549 1.0 ug DNA Ask for price

KRTAP5-10 ORF Vector (Human) (pORF)

ORF022550 1.0 ug DNA
EUR 486

KRTAP5-11 ORF Vector (Human) (pORF)

ORF022551 1.0 ug DNA Ask for price

KRTAP5-13P ORF Vector (Human) (pORF)

ORF022552 1.0 ug DNA Ask for price

KRTAP5-14P ORF Vector (Human) (pORF)

ORF022553 1.0 ug DNA Ask for price

KRTAP5-2 ORF Vector (Human) (pORF)

ORF022554 1.0 ug DNA
EUR 486

KRTAP5-3 ORF Vector (Human) (pORF)

ORF022555 1.0 ug DNA Ask for price

KRTAP5-5 ORF Vector (Human) (pORF)

ORF022557 1.0 ug DNA Ask for price

KRTAP5-7 ORF Vector (Human) (pORF)

ORF022558 1.0 ug DNA
EUR 486

KRTAP5-8 ORF Vector (Human) (pORF)

ORF022559 1.0 ug DNA Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG

6781-4 1/pk
EUR 957.6
Description: Lab Equipment; Shakers & Mixers

Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat

4-20234 ea Ask for price

Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse

4-20324 ea Ask for price

Pancreas Dissociation System 4 (Islets), Mouse and Rat

4-20374 ea Ask for price

Skin Dissociation System 4 (Keratinocytes), Mouse and Rat

4-20434 ea Ask for price

Pesticide Mix 4 Containing 15 Compounds in Acetonitrile

SPXPR-4 1ML
EUR 175.56

Adipose/Fat Dissociation System 4 (Predipocytes), Mouse and Rat

4-20194 ea Ask for price

Brain Dissociation System 4 (Endothelial, Microvessels), Mouse and Rat

4-20224 ea Ask for price

Endothelial Dissociation System 4 (Endothelial,Cerebral), Mouse and Rat

4-20244 ea Ask for price

Heart Dissociation System 4 (Myocytes,Ventricles), Mouse and Rat

4-20274 ea Ask for price

Muscle Dissociation System 4 (Smooth muscle), Mouse and Rat

4-20334 ea Ask for price

Parotid Dissociation System 4 (Parotid acinar), Mouse and Rat

4-20394 ea Ask for price

Epithelial Dissociation System 4 (Epithelial,Submandibular salivary), Mouse and Rat

4-20254 ea Ask for price

Heart Dissociation System 4 (Retinal pigment epithelial), Mouse and Rat

4-20294 ea Ask for price

Lung Dissociation System 4 (Alveolar type II), Mouse and Rat

4-20314 ea Ask for price

Reproductive Tissue Dissociation System 4 (Epithelial, vagina), Mouse and Rat

4-20414 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 4 vials)

M1040-4 each
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 4 vials)

M1041-4 each
EUR 1364.4

ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 4 vials)

M1042-4 each
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 4 vials)

M1043-4 each
EUR 1358.4

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4 each
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials)

M1045-4 each
EUR 1364.4

ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 4 vials)

M1046-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 4 vials)

M1047-4 each
EUR 1364.4

ExoStd? Lyophilized Exosome Standard (30 µg, U87 MG, 4 vials)

M1054-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, U87 MG, 4 vials)

M1055-4 each
EUR 1370.4

KRTAP5-9 cloning plasmid

CSB-CL012673HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the KRTAP5-9 gene.

KRTAP5-6 cloning plasmid

CSB-CL750447HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the KRTAP5-6 gene.

pCR4-TOPO-KRTAP5-2

PVT18019 2 ug
EUR 277.2

pCR4-TOPO-KRTAP5-9

PVT18039 2 ug
EUR 277.2

pCR4-TOPO-KRTAP5-11

PVT18069 2 ug
EUR 277.2

ICP-MS Tuning Solution 4

CL-TUNE-4 125ML
EUR 126.54

Turbidity Std Ratio 4 NTU

CRSR-4-500 500ML
EUR 181.26

Adrenal Dissociation System 4 (Heart, Adrenal chromaffin, Paraneurons), Mouse and Rat

4-20204 ea Ask for price

Kidney Dissociation System 4 (Inner medullary duct,Papillae), Mouse and Rat

4-29294 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, COLO1 cell line, 4 vials)

M1048-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, COLO1 cell line, 4 vials)

M1049-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, MM1 cell line, 4 vials)

M1050-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, MM1 cell line, 4 vials)

M1051-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, BLCL21 cell line, 4 vials)

M1052-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, BLCL21 cell line, 4 vials)

M1053-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, HCT116 cell line, 4 vials)

M1058-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, HCT116 cell line, 4 vials)

M1059-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, PC3 cell line, 4 vials)

M1060-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, PC3 cell line, 4 vials)

M1061-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, DAUD1 cell line, 4 vials)

M1064-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, DAUD1 cell line, 4 vials)

M1065-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, A549 cell line, 4 vials)

M1066-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, A549 cell line, 4 vials)

M1067-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, B16F10 cell line, 4 vials)

M1070-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, B16F10 cell line, 4 vials)

M1071-4 each
EUR 1370.4

KRTAP5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1182805 3 x 1.0 ug
EUR 451.2

Krtap5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3047105 3 x 1.0 ug
EUR 451.2

Tumor Dissociation System 4 (Epithelial tumor,Neoplastic, Tumor, islet), Mouse and Rat

4-20484 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, BPH-1 cell line, 4 vials)

M1062-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, BPH-1 cell line, 4 vials)

M1063-4 each
EUR 1370.4

ExoStd? Lyophilized Exosome Standard (30 µg, K-562 cell line, 4 vials)

M1068-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, K-562 cell line, 4 vials)

M1069-4 each
EUR 1370.4

KRTAP5-13P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV730662 1.0 ug DNA Ask for price

KRTAP5-13P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV730663 1.0 ug DNA Ask for price

KRTAP5-13P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV730664 1.0 ug DNA Ask for price

KRTAP5-14P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV730668 1.0 ug DNA Ask for price

KRTAP5-14P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV730669 1.0 ug DNA Ask for price

KRTAP5-14P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV730670 1.0 ug DNA Ask for price

ICP-MS Instrument Check Standard 4

CL-ICS-4 125ML
EUR 112.86

Turbidity Std Non Ratio 4 NTU

CRS-4-100 100ML
EUR 84.36

Turbidity Std Non Ratio 4 NTU

CRS-4-500 500ML
EUR 336.3

ExoStd? Lyophilized Exosome Standard (30 µg, SK-N-SH cell line, 4 vials)

M1056-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, SK-N-SH cell line, 4 vials)

M1057-4 each
EUR 1370.4

Quantifoil R 2/4

M-CEM-Q2100AR-4 100 GRIDS
EUR 895
Description: Quantifoil R 2/4; Gold 200 Mesh 100/pk

Quantifoil R 2/4

M-CEM-Q2100CR-4 100 GRIDS
EUR 700
Description: Quantifoil R 2/4; Copper 200 Mesh 100/pk

Quantifoil R 2/4

M-CEM-Q2100NR-4 100 GRIDS
EUR 800
Description: Quantifoil R 2/4; Nickel 200 Mesh 100/pk

Canadian Pesticide Mix 4 Containing 19 Compounds

CAN-CAN-4 1ML
EUR 123.12

KRTAP5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1182806 1.0 ug DNA
EUR 200.4

KRTAP5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1182807 1.0 ug DNA
EUR 200.4

KRTAP5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1182808 1.0 ug DNA
EUR 200.4

Krtap5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3047106 1.0 ug DNA
EUR 200.4

Krtap5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3047107 1.0 ug DNA
EUR 200.4

Krtap5-4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3047108 1.0 ug DNA
EUR 200.4

Mouse KRTAP5-5 shRNA Plasmid

20-abx980176
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-1 shRNA Plasmid

20-abx967730
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-3 shRNA Plasmid

20-abx967731
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-10 shRNA Plasmid

20-abx967733
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-5 shRNA Plasmid

20-abx968221
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-2 shRNA Plasmid

20-abx968224
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-6 shRNA Plasmid

20-abx968225
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-7 shRNA Plasmid

20-abx968228
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-11 shRNA Plasmid

20-abx968229
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse KRTAP5-2 shRNA Plasmid

20-abx977442
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-8 shRNA Plasmid

20-abx961693
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human KRTAP5-9 shRNA Plasmid

20-abx952608
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse KRTAP5-1 shRNA Plasmid

20-abx974115
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

KRTAP5-9 Recombinant Protein (Human)

RP017422 100 ug Ask for price

KRTAP5-6 Recombinant Protein (Human)

RP040606 100 ug Ask for price

KRTAP5-1 Recombinant Protein (Human)

RP067644 100 ug Ask for price

KRTAP5-10 Recombinant Protein (Human)

RP067647 100 ug Ask for price

KRTAP5-11 Recombinant Protein (Human)

RP067650 100 ug Ask for price

KRTAP5-13P Recombinant Protein (Human)

RP067653 100 ug Ask for price

KRTAP5-14P Recombinant Protein (Human)

RP067656 100 ug Ask for price

KRTAP5-2 Recombinant Protein (Human)

RP067659 100 ug Ask for price

KRTAP5-3 Recombinant Protein (Human)

RP067662 100 ug Ask for price

KRTAP5-5 Recombinant Protein (Human)

RP067668 100 ug Ask for price

KRTAP5-7 Recombinant Protein (Human)

RP067671 100 ug Ask for price

KRTAP5-8 Recombinant Protein (Human)

RP067674 100 ug Ask for price

KRTAP5-1 Recombinant Protein (Mouse)

RP146663 100 ug Ask for price

KRTAP5-2 Recombinant Protein (Mouse)

RP146666 100 ug Ask for price

KRTAP5-3 Recombinant Protein (Mouse)

RP146669 100 ug Ask for price

KRTAP5-5 Recombinant Protein (Mouse)

RP146675 100 ug Ask for price

KRTAP5-1 Protein Vector (Human) (pPB-C-His)

PV090194 500 ng Ask for price

KRTAP5-1 Protein Vector (Human) (pPB-N-His)

PV090195 500 ng Ask for price

KRTAP5-1 Protein Vector (Human) (pPM-C-HA)

PV090196 500 ng Ask for price

KRTAP5-1 Protein Vector (Human) (pPM-C-His)

PV090197 500 ng Ask for price

KRTAP5-10 Protein Vector (Human) (pPB-C-His)

PV090198 500 ng
EUR 662.4
These outcomes present {that a} single injection with focused lentiviral vectors might be an efficient immunotherapy for breast most cancers. Moreover, they could possibly be mixed with different immunotherapeutic regimens to enhance outcomes for sufferers with breast most cancers.

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